Scientific Computing Seminar
Abstract:
Spatial heterogeneity of molecules or cells is functionally important to
biological systems, and it is often achieved or induced by cell signaling. One
of the central questions in cell and developmental biology is to identify and
understand the underlying mechanisms of the emergence, the robustness and the
dynamics of the spatial patterning. In this talk, I will present our study on
two biological systems: (1) cell polarization in yeast pheromone sensing, (2)
multi-stage cell lineage in epithelium, in which we investigated the strategic
control of the systems through modeling with partial differential equations
and computational analysis.
In addition to modeling, I will also discuss computational challenges that
arise from exploring such biological models.